Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Data and Resource Coordination Center (CAP-IT DRCC) (U24 Clinical Trial Not Allowed) | RFA CA 21 039

Opportunity Information: Apply for RFA CA 21 039

The National Institutes of Health (NIH) released this Funding Opportunity Announcement (FOA), RFA-CA-21-039, to fund a single Data and Resource Coordination Center (DRCC) for the Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT). The award mechanism is a U24 cooperative agreement, meaning the NIH will have substantial programmatic involvement and the funded center will be expected to work in close coordination with NIH staff and the rest of the CAP-IT network. Clinical trials are not allowed under this FOA. The application due date listed for the original announcement was October 7, 2021, and the program is associated with CFDA numbers 93.394 and 93.395.

CAP-IT is designed to build an agile, collaborative network focused on precision cancer prevention and interception. The larger scientific aim, shared by this U24 FOA and a companion U54 FOA for CAP-IT Specialized Centers, is to accelerate discovery of targeted agents that can prevent cancer from developing or intercept the oncogenic process early, particularly in higher-risk populations. In plain terms, the program is about finding and prioritizing molecularly targeted or immunologically targeted interventions that can stop cancer before it becomes established disease, using modern insights into risk, biology, and immune-oncology. The CAP-IT network structure is envisioned as up to three U54 Specialized Centers carrying out the discovery and related research activities, supported by one U24 DRCC that provides the backbone services needed to operate the network efficiently.

The CAP-IT DRCC is intended to function as the centralized hub for data management and network coordination. While the FOA text provided does not spell out every task, the typical expectations for an NIH network DRCC in this kind of cooperative agreement include building and maintaining shared data systems; setting up common data standards and dictionaries; supporting data submission, curation, quality control, and secure sharing across participating centers; coordinating cross-site communications and network activities; and helping the program operate as an integrated whole rather than as separate projects. In practice, the DRCC usually enables consistent reporting and harmonization of research outputs, supports collaboration logistics (for example, scheduling network meetings and maintaining documentation), and helps ensure that data and resources produced across the U54 Centers can be found, accessed, and used by the network in a timely and organized way. The core idea is that the DRCC reduces friction, improves consistency, and speeds up collective progress toward discovering and advancing prevention and interception agents.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants listed include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

Foreign participation is restricted in specific ways. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as the applicant organization. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant may include certain discrete foreign elements of the project when adequately justified and when consistent with NIH policy, even though a foreign institution cannot be the primary applicant.

Overall, this FOA is about building the operational and data coordination engine for a multi-center NIH prevention and interception discovery network. The U24 DRCC is expected to make it possible for up to three U54 Specialized Centers to work as a coherent program by providing centralized data stewardship and coordinating network-wide activities, all in service of identifying and advancing targeted agents aimed at preventing cancer or interrupting its development in people at elevated risk.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Data and Resource Coordination Center (CAP-IT DRCC) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
• This funding opportunity was created on 2021-07-15.
• Applicants must submit their applications by 2021-10-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 21 039

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