Opportunity Information: Apply for RFA DP 23 001
This funding opportunity (RFA DP 23 001) from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), supports rapid, applied research that tests how real-world programs, policies, or environmental improvement strategies change social determinants of health (SDOH) and, in turn, improve chronic disease outcomes and reduce health disparities. The emphasis is on rigorous, practice-relevant evaluation approaches rather than purely descriptive studies. CDC is looking for work that can credibly estimate the effects of interventions already happening in communities or systems, using strong designs such as natural experiments and quasi-experimental studies, along with tools like simulation modeling and economic evaluation. Funded recipients are expected to collaborate as a network, meaning the program is designed not just to support stand-alone projects, but to produce a coordinated body of evidence that is comparable, scalable, and useful for public health decision-making.
The NOFO is structured around three components. Component A focuses on applied epidemiologic research to assess inequities in chronic disease outcomes and determine whether and how these inequities are reduced by ongoing interventions that target SDOH. In practice, this means studying policies or programs that influence conditions like housing stability, transportation, neighborhood environments, food access, education, employment, or healthcare access, and then measuring downstream effects on chronic disease outcomes and disparities across populations. The methods called out for this component (natural experiments and quasi-experimental designs) signal an expectation that applicants will use approaches capable of approximating causal inference in non-randomized settings, such as difference-in-differences, interrupted time series, regression discontinuity, matched comparison groups, or other robust counterfactual strategies.
Component B shifts from direct evaluation to a systems science lens, supporting studies that build simulation models to represent how multiple SDOH factors interact over time and how those interactions shape chronic disease and inequities. The goal is to generate long-term projections (for example, 10-, 20-, or 30-year horizons) of health outcomes and disparities, including measures like quality-adjusted life-years, while also estimating costs and cost-effectiveness of the policy, program, or strategy being modeled. This component is intended to help decision-makers understand not only whether an intervention might work, but how impacts could accumulate over time, how benefits and burdens might differ across groups, and what tradeoffs exist when considering resources, budget impacts, and value for money.
Component C is a coordinating center designed to knit the overall initiative together. Rather than running its own independent research question, the coordinating center provides organizational, logistical, and communication support so that Component A and B awardees can function as an efficient network. Typical coordinating functions in efforts like this include convening meetings, supporting cross-site collaboration, helping align common measures or reporting practices, facilitating dissemination of findings, and improving overall public health impact by making results easier to translate into policy and practice. Importantly, applicants may apply for Component A or Component B, but Component C is only available to applicants who also apply for (and are funded under) Component A or B, meaning coordination is anchored in an active research site.
Operationally, this is a discretionary cooperative agreement, which generally implies substantial involvement from CDC staff compared with a standard grant, often through collaboration on priorities, evaluation rigor, or dissemination plans. The opportunity was created November 22, 2022, with an original application deadline of February 9, 2023 (applications due by 5:00 PM ET). The award ceiling is $1,000,000, and CDC anticipated making about 12 awards. Eligibility is broad and includes state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses, with final eligibility subject to any additional instructions in the full announcement.
Overall, the NOFO is aimed at producing actionable evidence on what works to improve SDOH in ways that measurably reduce chronic disease burden and close equity gaps. It prioritizes credible evaluation of real-world actions already underway, paired with modeling and economic analysis that can inform long-term planning and investment decisions, and it builds in a network structure so findings can be strengthened through shared learning and coordinated dissemination.Apply for RFA DP 23 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Assessing the Effectiveness of Programs, Policies, or Practices that Affect Social Determinants of Health to Promote Health Equity and Reduce Health Disparities in Chronic Diseases" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068.
- This funding opportunity was created on Nov 22, 2022.
- Applicants must submit their applications by Feb 09, 2023 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Applicants who have applied for this opportunity (RFA DP 23 001) also looked into and applied for these:
| Funding Opportunity |
|---|
| Approach to Adult Vaccine Counseling Apply for RFA IP 23 005 Funding Number: RFA IP 23 005 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $500,000 |
| Rural Quality Improvement Technical Assistance Cooperative Agreement Apply for HRSA 23 042 Funding Number: HRSA 23 042 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $640,000 |
| Enhancing Capacity for Strategic and Applied Research Activities in Support of Control and Elimination of Neglected Tropical Diseases Apply for RFA GH 23 001 Funding Number: RFA GH 23 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $1,500,000 |
| Systems to End the Malaria Burden Through Meaningful Engagement - I (SEMBE I) Apply for 72062423RFA00002 Funding Number: 72062423RFA00002 Agency: Agency for International Development, Ghana USAID-Accra Category: Health Funding Amount: $30,000,000 |
| Strengthening Training, Evaluation, and Partnerships in the Prevention and Control of Vector-Borne Diseases Apply for CDC RFA CK 23 0005 Funding Number: CDC RFA CK 23 0005 Agency: Department of Health and Human Services, Centers for Disease Control - NCEZID Category: Health Funding Amount: Case Dependent |
| Rural Health Innovation and Transformation Technical Assistance Apply for HRSA 23 047 Funding Number: HRSA 23 047 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $500,000 |
| Ambassador's Special Self-Help Program - PEPFAR Small Grants Fund Apply for 005 2022 Funding Number: 005 2022 Agency: Department of State, U.S. Mission to Zimbabwe Category: Health Funding Amount: $20,000 |
| Conducting Public Health Research with Universities in Thailand Apply for RFA GH 23 003 Funding Number: RFA GH 23 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $400,000 |
| Research Grants to Rigorously Evaluate Innovative and Promising Strategies to Prevent Firearm-Related Violence and Injuries (R01) Apply for RFA CE 23 006 Funding Number: RFA CE 23 006 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $650,000 |
| USAID Free State Province Orphans and Vulnerable Children Activity – RFI Apply for EXT RFI 674 23 FREESTATE Funding Number: EXT RFI 674 23 FREESTATE Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: Case Dependent |
| USAID North West Province Orphans and Vulnerable Children Activity – RFI Apply for EXT RFI 674 23 NORTHWEST Funding Number: EXT RFI 674 23 NORTHWEST Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: Case Dependent |
| USAID Limpopo Province Orphans and Vulnerable Children Activity – RFI Apply for EXT RFI 674 23 LIMPOPO Funding Number: EXT RFI 674 23 LIMPOPO Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: Case Dependent |
| Research Grants to Inform Firearm-Related Violence and Injury Prevention Strategies (R01) Apply for RFA CE 23 005 Funding Number: RFA CE 23 005 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $650,000 |
| Tribal Management Grant Program Apply for HHS 2023 IHS TMD 0001 Funding Number: HHS 2023 IHS TMD 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Health Funding Amount: $150,000 |
| Rural Communities Opioid Response Program-Neonatal Abstinence Syndrome Apply for HRSA 23 094 Funding Number: HRSA 23 094 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $500,000 |
| Strengthen Sustainable HIV Prevention and Impact Mitigation Services for Vulnerable Children and Youth Activity in Eswatini Apply for 72067423RFA00005 Funding Number: 72067423RFA00005 Agency: Agency for International Development, South Africa USAID-Pretoria Category: Health Funding Amount: $34,000,000 |
| Nurse Anesthetist Traineeship (NAT) Program Apply for HRSA 23 002 Funding Number: HRSA 23 002 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| State Public Health Approaches to Addressing Arthritis Apply for CDC RFA DP 23 0001 Funding Number: CDC RFA DP 23 0001 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $550,000 |
| School-Based Interventions to Promote Equity and Improve Health, Academic Achievement, and Well-Being of Students Apply for CDC RFA DP 23 0002 Funding Number: CDC RFA DP 23 0002 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $425,000 |
| Health Promotion and Disease Prevention Research Centers: 2023 Special Interest Project Competitive Supplement (SIPS) Apply for RFA DP 23 004 Funding Number: RFA DP 23 004 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $500,000 |
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