Opportunity Information: Apply for RFA DP 23 001
This funding opportunity (RFA DP 23 001) from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), supports rapid, applied research that tests how real-world programs, policies, or environmental improvement strategies change social determinants of health (SDOH) and, in turn, improve chronic disease outcomes and reduce health disparities. The emphasis is on rigorous, practice-relevant evaluation approaches rather than purely descriptive studies. CDC is looking for work that can credibly estimate the effects of interventions already happening in communities or systems, using strong designs such as natural experiments and quasi-experimental studies, along with tools like simulation modeling and economic evaluation. Funded recipients are expected to collaborate as a network, meaning the program is designed not just to support stand-alone projects, but to produce a coordinated body of evidence that is comparable, scalable, and useful for public health decision-making.
The NOFO is structured around three components. Component A focuses on applied epidemiologic research to assess inequities in chronic disease outcomes and determine whether and how these inequities are reduced by ongoing interventions that target SDOH. In practice, this means studying policies or programs that influence conditions like housing stability, transportation, neighborhood environments, food access, education, employment, or healthcare access, and then measuring downstream effects on chronic disease outcomes and disparities across populations. The methods called out for this component (natural experiments and quasi-experimental designs) signal an expectation that applicants will use approaches capable of approximating causal inference in non-randomized settings, such as difference-in-differences, interrupted time series, regression discontinuity, matched comparison groups, or other robust counterfactual strategies.
Component B shifts from direct evaluation to a systems science lens, supporting studies that build simulation models to represent how multiple SDOH factors interact over time and how those interactions shape chronic disease and inequities. The goal is to generate long-term projections (for example, 10-, 20-, or 30-year horizons) of health outcomes and disparities, including measures like quality-adjusted life-years, while also estimating costs and cost-effectiveness of the policy, program, or strategy being modeled. This component is intended to help decision-makers understand not only whether an intervention might work, but how impacts could accumulate over time, how benefits and burdens might differ across groups, and what tradeoffs exist when considering resources, budget impacts, and value for money.
Component C is a coordinating center designed to knit the overall initiative together. Rather than running its own independent research question, the coordinating center provides organizational, logistical, and communication support so that Component A and B awardees can function as an efficient network. Typical coordinating functions in efforts like this include convening meetings, supporting cross-site collaboration, helping align common measures or reporting practices, facilitating dissemination of findings, and improving overall public health impact by making results easier to translate into policy and practice. Importantly, applicants may apply for Component A or Component B, but Component C is only available to applicants who also apply for (and are funded under) Component A or B, meaning coordination is anchored in an active research site.
Operationally, this is a discretionary cooperative agreement, which generally implies substantial involvement from CDC staff compared with a standard grant, often through collaboration on priorities, evaluation rigor, or dissemination plans. The opportunity was created November 22, 2022, with an original application deadline of February 9, 2023 (applications due by 5:00 PM ET). The award ceiling is $1,000,000, and CDC anticipated making about 12 awards. Eligibility is broad and includes state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses, with final eligibility subject to any additional instructions in the full announcement.
Overall, the NOFO is aimed at producing actionable evidence on what works to improve SDOH in ways that measurably reduce chronic disease burden and close equity gaps. It prioritizes credible evaluation of real-world actions already underway, paired with modeling and economic analysis that can inform long-term planning and investment decisions, and it builds in a network structure so findings can be strengthened through shared learning and coordinated dissemination.Apply for RFA DP 23 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Assessing the Effectiveness of Programs, Policies, or Practices that Affect Social Determinants of Health to Promote Health Equity and Reduce Health Disparities in Chronic Diseases" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068.
- This funding opportunity was created on Nov 22, 2022.
- Applicants must submit their applications by Feb 09, 2023 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is this funding opportunity (RFA DP 23 001) trying to support?
This CDC funding opportunity supports rapid, applied research that tests how real-world programs, policies, or environmental improvement strategies affect social determinants of health (SDOH) and, in turn, improve chronic disease outcomes and reduce health disparities. The focus is on producing actionable evidence that public health decision-makers can use.
Which federal agency is offering this opportunity?
The opportunity is offered by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).
What kinds of studies does CDC emphasize for this NOFO?
CDC emphasizes rigorous, practice-relevant evaluation approaches rather than purely descriptive studies. The NOFO highlights designs that can credibly estimate intervention effects in non-randomized, real-world settings (for example, natural experiments and quasi-experimental studies), along with tools such as simulation modeling and economic evaluation.
Does this opportunity focus on new interventions or existing real-world actions?
The emphasis is on evaluating interventions that are already happening in communities or systems, and estimating their effects using strong evaluation designs suited to real-world conditions.
How is the NOFO organized?
The NOFO is structured around three components: Component A (applied epidemiologic evaluation), Component B (systems science and simulation modeling), and Component C (a coordinating center that supports network functioning).
What is Component A?
Component A focuses on applied epidemiologic research to assess inequities in chronic disease outcomes and determine whether and how those inequities are reduced by ongoing interventions that target SDOH. This includes studying policies or programs that affect conditions such as housing stability, transportation, neighborhood environments, food access, education, employment, or healthcare access, and then measuring downstream effects on chronic disease outcomes and disparities across populations.
What evaluation methods are specifically encouraged under Component A?
The NOFO calls out natural experiments and quasi-experimental designs. Examples named or implied include difference-in-differences, interrupted time series, regression discontinuity, matched comparison groups, and other robust counterfactual strategies intended to approximate causal inference in non-randomized settings.
What is Component B?
Component B supports a systems science approach by funding studies that build simulation models representing how multiple SDOH factors interact over time and how those interactions shape chronic disease outcomes and inequities.
What is the goal of the simulation modeling in Component B?
The goal is to generate long-term projections (for example, 10-, 20-, or 30-year horizons) of health outcomes and disparities and to estimate costs and cost-effectiveness of the modeled policy, program, or strategy. This is intended to help decision-makers understand how impacts may accumulate over time, how effects may differ across groups, and what resource or budget tradeoffs may exist.
Does Component B include economic evaluation?
Yes. Component B is intended to include estimating costs and cost-effectiveness, and it mentions outcomes such as quality-adjusted life-years (QALYs) as examples of measures that may be included.
What is Component C?
Component C is a coordinating center designed to knit the initiative together by providing organizational, logistical, and communication support so Component A and B awardees can function as an efficient network. Typical functions include convening meetings, supporting cross-site collaboration, helping align common measures or reporting practices, facilitating dissemination, and improving translation of results into policy and practice.
Can an applicant apply for Component C by itself?
No. Component C is only available to applicants who also apply for (and are funded under) Component A or Component B. Coordination is anchored in an active research site.
Are awardees expected to work together, or can projects operate independently?
Awardees are expected to collaborate as a network. The program is designed to produce a coordinated body of evidence that is comparable, scalable, and useful for public health decision-making, not just stand-alone projects.
What does it mean that this is a discretionary cooperative agreement?
A discretionary cooperative agreement generally implies substantial involvement from CDC staff compared with a standard grant, often through collaboration on priorities, evaluation rigor, and/or dissemination plans.
What types of SDOH interventions are relevant to this NOFO?
The NOFO describes interventions affecting SDOH domains such as housing stability, transportation, neighborhood environments, food access, education, employment, and healthcare access, with the intent to measure downstream impacts on chronic disease outcomes and disparities.
What is the ultimate public health purpose of this NOFO?
The NOFO aims to generate actionable evidence on what works to improve SDOH in ways that measurably reduce chronic disease burden and close equity gaps, pairing credible evaluation of real-world actions with modeling and economic analysis to inform longer-term planning and investment decisions.
When was this opportunity created, and what was the application deadline?
The opportunity was created November 22, 2022. The original application deadline was February 9, 2023, with applications due by 5:00 PM ET.
What is the maximum award amount (award ceiling)?
The award ceiling is $1,000,000.
How many awards did CDC anticipate making?
CDC anticipated making about 12 awards.
Who is eligible to apply based on the information provided?
Eligibility is broad and includes state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses. Final eligibility is subject to any additional instructions in the full announcement.
Are both nonprofit and for-profit organizations eligible?
Yes. The eligibility list includes nonprofit organizations (with or without 501(c)(3) status) and for-profit organizations (other than small businesses) as well as small businesses, subject to the full announcement requirements.
Does the NOFO specify expectations about the strength of evidence?
Yes. The NOFO prioritizes work that can credibly estimate the effects of interventions already underway, using strong evaluation designs such as natural experiments and quasi-experimental studies, and it also highlights simulation modeling and economic evaluation as complementary approaches.
Is this NOFO focused on chronic disease and equity?
Yes. It is centered on improving chronic disease outcomes and reducing health disparities by evaluating and modeling how SDOH changes affect inequities over time.
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