Opportunity Information: Apply for RFA RM 18 023
The National Institutes of Health (NIH) funding opportunity titled "Innovative Technologies to Deliver Genome Editing Machinery to Disease-relevant Cells and Tissues (UG3/UH3 Clinical Trial Not Allowed)" supports research aimed at solving one of the biggest practical hurdles in therapeutic genome editing: getting the editing tools into the right somatic cells and tissues safely and efficiently. The overall goal is to speed progress toward genome editing-based treatments for human disease by advancing delivery technologies that can reliably transport genome editing machinery (such as nucleases and associated components) to disease-relevant targets in the body. A key boundary of the announcement is that it does not allow clinical trials, meaning the work is intended to stay in preclinical or technology-development stages rather than testing interventions in human participants.
This opportunity uses a cooperative agreement mechanism and specifically the UG3/UH3 phased award structure. In practical terms, that structure is typically designed to fund a milestone-driven project in two stages: an initial phase focused on feasibility, development, and early validation (UG3), followed by an expansion phase to further optimize, scale, and demonstrate performance if predefined milestones are met (UH3). Because it is a cooperative agreement, NIH involvement is generally more hands-on than with a standard grant, with program staff often collaborating on progress assessment, milestones, and coordination. The emphasis on "innovative approaches" signals that the program is looking for new or significantly improved delivery strategies, not just incremental refinements of well-established methods, with an expectation that the work will be evaluated rigorously in relevant models and settings.
The funding opportunity number is RFA-RM-18-023, and it falls under the health category with CFDA number 93.310. The instrument type is listed as a cooperative agreement, and the opportunity is categorized as discretionary funding. The original closing date for submissions was October 18, 2018, and the opportunity record shows a creation date of July 25, 2018. The listed award ceiling is $500,000. While the record includes a field for expected awards, no specific number is provided in the source data shared, so applicants would have needed to consult the full FOA or NIH postings at the time for any program-level projections about how many awards might be made.
Eligibility is broad and includes a wide range of organization types across the public, private, nonprofit, and academic sectors. Eligible applicants include state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education and private institutions of higher education. The eligibility list also includes Native American tribal governments (federally recognized), public housing authorities and Indian housing authorities, and Native American tribal organizations that are not federally recognized tribal governments. Nonprofit organizations are eligible whether they have 501(c)(3) status or not (as long as they are not institutions of higher education), and for-profit organizations other than small businesses may apply, along with small businesses. The announcement also explicitly calls out additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, and eligible agencies of the federal government. It also indicates that non-domestic (non-U.S.) entities (foreign organizations), regional organizations, tribal governments other than federally recognized tribes, and U.S. territories or possessions are eligible, reflecting an intent to include diverse institutional participants and potentially global expertise in delivery technologies.
In short, this NIH program was designed to push the field of genome editing forward by funding the development and evaluation of delivery systems that can bring genome editing machinery to the specific somatic cells and tissues implicated in disease, under a milestone-based UG3/UH3 cooperative agreement structure, with no clinical trials allowed and with broad eligibility spanning governmental, academic, nonprofit, and private-sector organizations, including many categories of minority-serving institutions and U.S. territories as well as foreign entities.Apply for RFA RM 18 023
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovative Technologies to Deliver Genome Editing Machinery to Disease-relevant Cells and Tissues (UG3/UH3 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2018-07-25.
- Applicants must submit their applications by 2018-10-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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