Opportunity Information: Apply for CDC RFA GH22 2227
The Masaka Regional Mechanism for Reaching and Sustaining Epidemic Control in the Republic of Uganda is a PEPFAR-supported funding opportunity released by the U.S. Centers for Disease Control and Prevention (CDC) under HHS. It was offered as a discretionary cooperative agreement (Funding Opportunity Number CDC RFA GH22 2227; CFDA 93.067, Health), meaning CDC expected to remain substantially involved in the work through collaboration, technical guidance, and oversight rather than simply issuing a grant and stepping back. The opportunity was posted on December 30, 2021, with an original application deadline of February 28, 2022 (applications due by 11:59 pm ET). Eligibility was listed as unrestricted, open to any type of entity as long as it met any additional criteria described in the full notice.
Programmatically, the award was designed to help Uganda reach and sustain HIV epidemic control in the Masaka Region by funding a comprehensive package of HIV and TB prevention, care, and treatment services. The focus is not only on expanding service delivery, but also on improving quality and ensuring the results can be sustained through stronger local systems. A major emphasis is HIV case finding, with particular attention to groups that are often harder to reach or have lower testing and treatment uptake, including men, young people, and key populations. The project also covers the full continuum of HIV care and treatment, aiming to move people rapidly from diagnosis to antiretroviral therapy (ART) and then to durable viral suppression, while also addressing gaps that typically lead to loss to follow-up.
The scope explicitly integrates tuberculosis prevention, diagnosis, and treatment, reflecting how closely TB and HIV epidemics overlap. In practical terms, this means strengthening screening for TB among people living with HIV, ensuring timely diagnostic services, and linking patients to effective TB therapy and preventive interventions. The program also includes prevention of mother-to-child transmission (PMTCT), ensuring pregnant and breastfeeding women can access HIV testing, immediate treatment when indicated, and infant services to reduce vertical transmission and improve maternal outcomes.
Another core component is improved clinical management for advanced HIV disease (AHD), which typically involves identifying patients with severe immunosuppression or advanced symptoms and providing enhanced diagnostic and treatment packages to reduce mortality. The notice also highlights integrating services for non-communicable diseases (NCDs) alongside HIV care to make services more convenient and patient-centered. This reflects a broader health systems approach where clients can address multiple chronic health needs in a coordinated way, rather than navigating separate clinics and appointment schedules.
On the prevention side, the opportunity includes scaling or maintaining voluntary medical male circumcision (VMMC) and HIV pre-exposure prophylaxis (PrEP). VMMC is a proven biomedical prevention intervention that reduces risk of heterosexual acquisition for men, and PrEP provides a highly effective prevention option for individuals at substantial risk, including members of key populations and others with ongoing exposure risk. The notice signals that these prevention interventions are meant to be delivered as part of a combined prevention strategy, aligned with local epidemiology and program data.
The opportunity also places strong weight on laboratory and strategic information (SI) services. This includes viral load testing, which is essential for monitoring ART effectiveness and confirming viral suppression at the population level, as well as recency surveillance, which helps programs understand where newer infections are occurring and adjust prevention and testing strategies accordingly. SI components typically also include strengthening routine data systems, data quality, analysis, and use of information for real-time decision-making to improve coverage and outcomes.
Implementation is framed as a health systems strengthening effort carried out in close coordination with Uganda's Ministry of Health (MOH). A key expectation is that the recipient will build the capacity of Regional Referral Hospitals (RRHs) and district health structures to support an effective, decentralized, and sustainable HIV/TB response. The notice further emphasizes collaboration with faith-based and community-based partners to improve people-centered service delivery, which often involves community engagement, linkage to care support, adherence counseling, differentiated service delivery models, and approaches that reduce stigma and improve retention.
The intended results are directly tied to progress toward and maintenance of the global 95-95-95 targets: 95 percent of people living with HIV knowing their status, 95 percent of those diagnosed receiving ART, and 95 percent of those on ART achieving viral suppression. In effect, the program aims to increase access, quality, and coverage across the HIV cascade while improving TB outcomes and strengthening the underlying systems that keep services functioning reliably over time.
Financially, CDC indicated an approximate total funding amount of $25,000,000 for Year 1, contingent on availability of funds. The notice lists the Year 1 award ceiling as $0, which typically signals that CDC did not set a cap for individual awards in the public summary even though it anticipated a specific total amount available. CDC expected to make one award, suggesting a single lead implementing partner would coordinate the regional mechanism and associated sub-partnerships to deliver the full package of services and systems improvements in Masaka Region.Apply for CDC RFA GH22 2227
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Masaka Regional Mechanism for Reaching and Sustaining Epidemic Control in the Republic of Uganda under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Dec 30, 2021.
- Applicants must submit their applications by Feb 28, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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